Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome‐Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2

Anastrozole is a widely prescribed aromatase inhibitor for the therapy of estrogen receptor positive (ER+) breast cancer. We performed a genome‐wide association study (GWAS) for plasma anastrozole concentrations in 687 postmenopausal women with ER+ breast cancer. The top single‐nucleotide polymorphi...

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Pubblicato in:Clin Pharmacol Ther
Autori principali: Dudenkov, Tanda M., Liu, Duan, Cairns, Junmei, Devarajan, Sandhya, Zhuang, Yongxian, Ingle, James N., Buzdar, Aman U., Robson, Mark E., Kubo, Michiaki, Batzler, Anthony, Barman, Poulami, Jenkins, Gregory D., Carlson, Erin E., Goetz, Matthew P., Northfelt, Donald W., Moreno‐Aspitia, Alvaro, Desta, Zeruesenay, Reid, Joel M., Kalari, Krishna R., Wang, Liewei, Weinshilboum, Richard M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612579/
https://ncbi.nlm.nih.gov/pubmed/30648747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1359
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