The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

BACKGROUND: Our previous genome-wide association study using the MA.27 aromatase inhibitors adjuvant trial identified SNPs in the long noncoding RNA MIR2052HG associated with breast cancer-free interval. MIR2052HG maintained ERα both by promoting AKT/FOXO3-mediated ESR1 transcription and by limiting...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Cairns, Junmei, Ingle, James N., Kalari, Krishna R., Shepherd, Lois E., Kubo, Michiaki, Goetz, Matthew P., Weinshilboum, Richard M., Wang, Liewei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448248/
https://ncbi.nlm.nih.gov/pubmed/30944027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-019-1130-3
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