Blocking the binding of WT1 to bcl-2 promoter by G-quadruplex ligand SYUIQ-FM05

At present, wt1, a Wilms’ tumor suppressor gene, is recognized as a critical regulator of tumorigenesis and a potential therapeutic target. WT1 shows the ability to regulate the transcription of bcl-2 by binding to a GC-rich region in the promoter, which can then fold into a special DNA secondary st...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biochem Biophys Rep
Main Authors: Xiong, Yun-Xia, Chen, Ai-Chun, Yao, Pei-Fen, Zeng, De-Ying, Lu, Yu-Jing, Tan, Jia-Heng, Huang, Zhi-Shu, Ou, Tian-Miao
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600358/
https://ncbi.nlm.nih.gov/pubmed/28955841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2015.12.014
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