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Blocking the binding of WT1 to bcl-2 promoter by G-quadruplex ligand SYUIQ-FM05
At present, wt1, a Wilms’ tumor suppressor gene, is recognized as a critical regulator of tumorigenesis and a potential therapeutic target. WT1 shows the ability to regulate the transcription of bcl-2 by binding to a GC-rich region in the promoter, which can then fold into a special DNA secondary st...
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| 出版年: | Biochem Biophys Rep |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Elsevier
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5600358/ https://ncbi.nlm.nih.gov/pubmed/28955841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2015.12.014 |
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