Synthesis and Evaluation of Quinazolone Derivatives as a New Class of c-KIT G-Quadruplex Binding Ligands

[Image: see text] The c-KIT G-quadruplex structures are a novel class of attractive targets for the treatment of gastrointestinal stromal tumor (GIST). Herein, a series of new quinazolone derivatives with the expansion of unfused aromatic ring system were designed and synthesized. Subsequent biophys...

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Xehetasun bibliografikoak
Egile Nagusiak: Wang, Xiaoxiao, Zhou, Chen-Xi, Yan, Jin-Wu, Hou, Jin-Qiang, Chen, Shuo-Bin, Ou, Tian-Miao, Gu, Lian-Quan, Huang, Zhi-Shu, Tan, Jia-Heng
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2013
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027236/
https://ncbi.nlm.nih.gov/pubmed/24900584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400271y
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