Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques

Evaluation of the epitope specificities, locations (systemic or mucosal), and effector functions of antibodies elicited by novel HIV-1 immunogens engineered to improve exposure of specific epitopes is critical for HIV-1 vaccine development. Utilizing an array of humoral assays, we evaluated the magn...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Shen, Xiaoying, Bogers, Willy M., Yates, Nicole L., Ferrari, Guido, Dey, Antu K., Williams, William T., Jaeger, Frederick H., Wiehe, Kevin, Sawant, Sheetal, Alam, S. Munir, LaBranche, Celia C., Montefiori, David C., Martin, Loic, Srivastava, Indresh, Heeney, Jonathan, Barnett, Susan W., Tomaras, Georgia D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599731/
https://ncbi.nlm.nih.gov/pubmed/28490585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00401-17
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