Superiority in Rhesus Macaques of Targeting HIV-1 Env gp140 to CD40 versus LOX-1 in Combination with Replication-Competent NYVAC-KC for Induction of Env-Specific Antibody and T Cell Responses

We compared the HIV-1-specific immune responses generated by targeting HIV-1 envelope protein (Env gp140) to either CD40 or LOX-1, two endocytic receptors on dendritic cells (DCs), in rhesus macaques primed with a poxvirus vector (NYVAC-KC) expressing Env gp140. The DC-targeting vaccines, humanized...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Zurawski, Gerard, Shen, Xiaoying, Zurawski, Sandra, Tomaras, Georgia D., Montefiori, David C., Roederer, Mario, Ferrari, Guido, Lacabaratz, Christine, Klucar, Peter, Wang, Zhiqing, Foulds, Kathryn E., Kao, Shing-Fen, Yu, Xuesong, Sato, Alicia, Yates, Nicole L., LaBranche, Celia, Stanfield-Oakley, Sherry, Kibler, Karen, Jacobs, Bertram, Salazar, Andres, Self, Steve, Fulp, William, Gottardo, Raphael, Galmin, Lindsey, Weiss, Deborah, Cristillo, Anthony, Pantaleo, Giuseppe, Levy, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391468/
https://ncbi.nlm.nih.gov/pubmed/28202751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01596-16
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