Addition of anti-estrogen therapy to anti-HER2 dendritic cell vaccination improves regional nodal immune response and pathologic complete response rate in patients with ER(pos)/HER2(pos) early breast cancer

HER2-directed therapies are less effective in patients with ER(pos) compared to ER(neg) breast cancer, possibly reflecting bidirectional activation between HER2 and estrogen signaling pathways. We investigated dual blockade using anti-HER2 vaccination and anti-estrogen therapy in HER2(pos)/ER(pos) e...

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Publicado en:Oncoimmunology
Autores principales: Lowenfeld, Lea, Zaheer, Salman, Oechsle, Crystal, Fracol, Megan, Datta, Jashodeep, Xu, Shuwen, Fitzpatrick, Elizabeth, Roses, Robert E., Fisher, Carla S., McDonald, Elizabeth S., Zhang, Paul J., DeMichele, Angela, Mick, Rosemarie, Koski, Gary K., Czerniecki, Brian J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2016
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599079/
https://ncbi.nlm.nih.gov/pubmed/28932627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1207032
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