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TREX1 dictates the immune fate of irradiated cancer cells
The optimal radiation dose and fractionation to induce anti-tumor immunity remain elusive. We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated cancer cells by degrading interferon-stimulatory cytosolic dsDNA. TREX1 upregulation by radiation dose per fraction beyon...
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| Publicat a: | Oncoimmunology |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5599078/ https://ncbi.nlm.nih.gov/pubmed/28932642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1339857 |
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