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TREX1 dictates the immune fate of irradiated cancer cells
The optimal radiation dose and fractionation to induce anti-tumor immunity remain elusive. We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated cancer cells by degrading interferon-stimulatory cytosolic dsDNA. TREX1 upregulation by radiation dose per fraction beyon...
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| Publicado no: | Oncoimmunology |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5599078/ https://ncbi.nlm.nih.gov/pubmed/28932642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1339857 |
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