Exosomes shuttle TREX1-sensitive IFN-stimulatory dsDNA from irradiated cancer cells to DCs

Radiotherapy (RT) used at immunogenic doses leads to accumulation of cytosolic double-stranded DNA (dsDNA) in cancer cells, which activates type I IFN (IFN-I) via the cGAS/STING pathway. Cancer cell-derived IFN-I is required to recruit BATF3-dependent dendritic cells (DCs) to poorly immunogenic tumo...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Diamond, Julie M., Vanpouille-Box, Claire, Spada, Sheila, Rudqvist, Nils-Petter, Chapman, Jessica R., Ueberheide, Beatrix M., Pilones, Karsten A., Sarfraz, Yasmeen, Formenti, Silvia C., Demaria, Sandra
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072562/
https://ncbi.nlm.nih.gov/pubmed/29907693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0581
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