Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA

Many pathogens, including Kaposi’s sarcoma herpesvirus (KSHV), lack tractable small animal models. KSHV persists as a multi-copy, nuclear episome in latently infected cells. KSHV latency-associated nuclear antigen (kLANA) binds viral terminal repeat (kTR) DNA to mediate episome persistence. Model pa...

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Dettagli Bibliografici
Pubblicato in:PLoS Pathog
Autori principali: Habison, Aline C., de Miranda, Marta Pires, Beauchemin, Chantal, Tan, Min, Cerqueira, Sofia A., Correia, Bruno, Ponnusamy, Rajesh, Usherwood, Edward J., McVey, Colin E., Simas, J. Pedro, Kaye, Kenneth M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599060/
https://ncbi.nlm.nih.gov/pubmed/28910389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006555
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