The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence

Kaposi sarcoma-associated herpesvirus (KSHV) has a causative role in several human malignancies. KSHV latency-associated nuclear antigen (LANA) mediates persistence of viral episomes in latently infected cells. LANA mediates KSHV DNA replication and segregates episomes to progeny nuclei. The structu...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Li, Shijun, Tan, Min, Juillard, Franceline, Ponnusamy, Rajesh, Correia, Bruno, Simas, J. Pedro, Carrondo, Maria A., McVey, Colin E., Kaye, Kenneth M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653668/
https://ncbi.nlm.nih.gov/pubmed/26420481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.674622
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