Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells

Sepsis is a systemic infection that enhances host vulnerability to secondary infections normally controlled by T cells. Using CLP sepsis model, we observed that sepsis induces apoptosis of circulating memory CD8 T-cells (T(CIRCM)) and diminishes their effector functions, leading to impaired CD8 T-ce...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Danahy, Derek B., Anthony, Scott M., Jensen, Isaac J., Hartwig, Stacey M., Shan, Qiang, Xue, Hai-Hui, Harty, John T., Griffith, Thomas S., Badovinac, Vladimir P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599054/
https://ncbi.nlm.nih.gov/pubmed/28910403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006569
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