Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections

The sepsis-induced cytokine storm leads to severe lymphopenia and reduced effector capacity of remaining/surviving cells. This results in a prolonged state of immunoparalysis, that contributes to enhanced morbidity/mortality of sepsis survivors upon secondary infection. The impact of sepsis on sever...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Jensen, Isaac J., Winborn, Christina S., Fosdick, Micaela G., Shao, Peng, Tremblay, Mikaela M., Shan, Qiang, Tripathy, Sandeep Kumar, Snyder, Christopher M., Xue, Hai-Hui, Griffith, Thomas S., Houtman, Jon C., Badovinac, Vladimir P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231673/
https://ncbi.nlm.nih.gov/pubmed/30379932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007405
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