Spatiotemporally Controlled Ablation of Klf5 Results in Dysregulated Epithelial Homeostasis in Adult Mouse Corneas

PURPOSE: Corneal epithelial (CE) homeostasis requires coordination between proliferation and differentiation. Here we examine the role of cell proliferation regulator Krüppel-like factor 5 (Klf5) in adult mouse CE homeostasis. METHODS: Klf5 was ablated in a spatiotemporally restricted manner by indu...

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Publicat a:Invest Ophthalmol Vis Sci
Autors principals: Loughner, Chelsea L., Tiwari, Anil, Kenchegowda, Doreswamy, Swamynathan, Sudha, Swamynathan, Shivalingappa K.
Format: Artigo
Idioma:Inglês
Publicat: The Association for Research in Vision and Ophthalmology 2017
Matèries:
Cornea
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5598321/
https://ncbi.nlm.nih.gov/pubmed/28910443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22498
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