Hyperosmotic stress enhances cytotoxicity of SMAC mimetics

Inhibitors of apoptosis (IAP) proteins contribute to cell death resistance in malignancies and emerged as promising targets in cancer therapy. Currently, small molecules mimicking the IAP-antagonizing activity of endogenous second mitochondria-derived activator of caspases (SMAC) are evaluated in ph...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Bittner, Sebastian, Knoll, Gertrud, Ehrenschwender, Martin
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596546/
https://ncbi.nlm.nih.gov/pubmed/28771230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.355
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