Triplebody Mediates Increased Anti-Leukemic Reactivity of IL-2 Activated Donor Natural Killer (NK) Cells and Impairs Viability of Their CD33-Expressing NK Subset

Natural killer cells (NK) are essential for the elimination of resistant acute myeloid and acute lymphoblastic leukemia (AML and ALL) cells. NK cell-based immunotherapies have already successfully entered for clinical trials, but limitations due to immune escape mechanisms were identified. Therefore...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Kloess, Stephan, Ede Valverde da Silva, Alessa, Oberschmidt, Olaf, Gardlowski, Tanja, Matthies, Nadine, Vyas, Maulik, Arseniev, Lubomir, Heuser, Michael, Pogge von Strandmann, Elke, Köhl, Ulrike
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596090/
https://ncbi.nlm.nih.gov/pubmed/28943878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01100
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