Mono- and dual-targeting triplebodies activate natural killer cells and have anti-tumor activity in vitro and in vivo against chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is the most common form of leukemia that affects B lymphocytes in adults. Natural killer (NK) cells in CLL patients are intrinsically potent but display poor in situ effector functions. NKG2D is an activating receptor found on NK and CD8(+) T cells and plays a role...

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Publicado no:Oncoimmunology
Main Authors: Vyas, Maulik, Schneider, Ann-Charlott, Shatnyeva, Olga, Reiners, Katrin S., Tawadros, Samir, Kloess, Stephan, Köhl, Ulrike, Hallek, Michael, Hansen, Hinrich P., Pogge von Strandmann, Elke
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5049355/
https://ncbi.nlm.nih.gov/pubmed/27757305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1211220
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