Zscan4 inhibits maintenance DNA methylation to facilitate telomere elongation in mouse embryonic stem cells

Proper telomere length is essential for embryonic stem cell (ESC) self-renewal and pluripotency. Mouse ESCs (mESCs) sporadically convert to a transient totipotent state similar to that of two-cell (2C) embryos to recover shortened telomeres. Zscan4, which exhibits a burst of expression in 2C-like mE...

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Udgivet i:Cell Rep
Main Authors: Dan, Jiameng, Rousseau, Philippe, Hardikar, Swanand, Veland, Nicolas, Wong, Jiemin, Autexier, Chantal, Chen, Taiping
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595351/
https://ncbi.nlm.nih.gov/pubmed/28834755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.07.070
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