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Zscan4 inhibits maintenance DNA methylation to facilitate telomere elongation in mouse embryonic stem cells
Proper telomere length is essential for embryonic stem cell (ESC) self-renewal and pluripotency. Mouse ESCs (mESCs) sporadically convert to a transient totipotent state similar to that of two-cell (2C) embryos to recover shortened telomeres. Zscan4, which exhibits a burst of expression in 2C-like mE...
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| Pubblicato in: | Cell Rep |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5595351/ https://ncbi.nlm.nih.gov/pubmed/28834755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.07.070 |
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