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Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation

Picornaviruses use internal ribosome entry sites (IRESs) to translate their genomes into protein. A typical feature of these IRESs is their ability to bind directly to the eukaryotic initiation factor (eIF) 4G component of the eIF4F cap-binding complex. Remarkably, the hepatitis A virus (HAV) IRES r...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Avanzino, Brian C., Fuchs, Gabriele, Fraser, Christopher S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594656/
https://ncbi.nlm.nih.gov/pubmed/28827335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704390114
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