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The cap-binding translation initiation factor, eIF4E, binds a pseudoknot in a viral cap-independent translation element

Eukaryotic initiation factor eIF4E performs a key early step in translation by specifically recognizing the m(7)GpppN cap structure at the 5' end of cellular mRNAs. Many viral mRNAs lack a 5' cap and thus bypass eIF4E. In contrast, we reported a novel cap-independent translation element (P...

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Main Authors: Wang, Zhaohui, Parisien, Marc, Scheets, Kay, Miller, W. Allen
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113551/
https://ncbi.nlm.nih.gov/pubmed/21645857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.03.013
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