ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population

BACKGROUND: ICG-001, a small molecule, binds CREB-binding protein (CBP) to disrupt its interaction with β-catenin and inhibits CBP function as a co-activator of Wnt/β-catenin-mediated transcription. Given its ability to inhibit Wnt/β-catenin signaling pathway, ICG-001 has been used in some tumor typ...

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Publicat a:J Exp Clin Cancer Res
Autors principals: Liu, Yi, Chen, Hui, Zheng, Peiming, Zheng, Yingxia, Luo, Qin, Xie, Guohua, Ma, Yanhui, Shen, Lisong
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594604/
https://ncbi.nlm.nih.gov/pubmed/28893318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0595-0
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