ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer

Germline mutations in ATM (encoding the DNA-damage signaling kinase, ataxia-telangiectasia-mutated) increase Familial Pancreatic Cancer (FPC) susceptibility, and ATM somatic mutations have been identified in resected human pancreatic tumors. Here we investigated how Atm contributes to pancreatic can...

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Udgivet i:Sci Rep
Main Authors: Drosos, Yiannis, Escobar, David, Chiang, Ming-Yi, Roys, Kathryn, Valentine, Virginia, Valentine, Marc B., Rehg, Jerold E., Sahai, Vaibhav, Begley, Lesa A., Ye, Jianming, Paul, Leena, McKinnon, Peter J., Sosa-Pineda, Beatriz
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593966/
https://ncbi.nlm.nih.gov/pubmed/28894253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11661-8
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