Expression of CD38 in myeloma bone niche: A rational basis for the use of anti-CD38 immunotherapy to inhibit osteoclast formation

It is known that multiple myeloma (MM) cells express CD38 and that a recently developed human anti-CD38 monoclonal antibody Daratumumab mediates myeloma killing. However, the expression of CD38 and other functionally related ectoenzymes within the MM bone niche and the potential effects of Daratumum...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Costa, Federica, Toscani, Denise, Chillemi, Antonella, Quarona, Valeria, Bolzoni, Marina, Marchica, Valentina, Vescovini, Rosanna, Mancini, Cristina, Martella, Eugenia, Campanini, Nicoletta, Schifano, Chiara, Bonomini, Sabrina, Accardi, Fabrizio, Horenstein, Alberto L., Aversa, Franco, Malavasi, Fabio, Giuliani, Nicola
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593586/
https://ncbi.nlm.nih.gov/pubmed/28915615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17896
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