Adenosine Generated in the Bone Marrow Niche Through a CD38-Mediated Pathway Correlates With Progression of Human Myeloma

Human myeloma cells express CD38 at high levels and grow in hypoxic niches inside the bone marrow. Myeloma cells respond to hypoxia with metabolic changes leading to aerobic glycolysis, thus reducing adenosine triphosphate (ATP) and increasing NAD(+). Our hypothesis is that these conditions favor th...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Horenstein, Alberto L, Quarona, Valeria, Toscani, Denise, Costa, Federica, Chillemi, Antonella, Pistoia, Vito, Giuliani, Nicola, Malavasi, Fabio
Formato: Artigo
Idioma:Inglês
Publicado em: Feinstein Institute for Medical Research 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135080/
https://ncbi.nlm.nih.gov/pubmed/27761584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2016.00198
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