Adenosine Generated in the Bone Marrow Niche Through a CD38-Mediated Pathway Correlates With Progression of Human Myeloma

Human myeloma cells express CD38 at high levels and grow in hypoxic niches inside the bone marrow. Myeloma cells respond to hypoxia with metabolic changes leading to aerobic glycolysis, thus reducing adenosine triphosphate (ATP) and increasing NAD(+). Our hypothesis is that these conditions favor th...

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Veröffentlicht in:Mol Med
Hauptverfasser: Horenstein, Alberto L, Quarona, Valeria, Toscani, Denise, Costa, Federica, Chillemi, Antonella, Pistoia, Vito, Giuliani, Nicola, Malavasi, Fabio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Feinstein Institute for Medical Research 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135080/
https://ncbi.nlm.nih.gov/pubmed/27761584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2016.00198
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