Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels

Opioids, agonists of µ-opioid receptors (µORs), are the strongest pain killers clinically available. Their action includes a strong central component, which also causes important adverse effects. However, µORs are also found on the peripheral endings of nociceptors and their activation there produce...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Dembla, Sandeep, Behrendt, Marc, Mohr, Florian, Goecke, Christian, Sondermann, Julia, Schneider, Franziska M, Schmidt, Marlene, Stab, Julia, Enzeroth, Raissa, Leitner, Michael G, Nuñez-Badinez, Paulina, Schwenk, Jochen, Nürnberg, Bernd, Cohen, Alejandro, Philipp, Stephan E, Greffrath, Wolfgang, Bünemann, Moritz, Oliver, Dominik, Zakharian, Eleonora, Schmidt, Manuela, Oberwinkler, Johannes
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2017
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593507/
https://ncbi.nlm.nih.gov/pubmed/28826482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26280
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