Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity

Cisplatin is among the most widely used anticancer drugs and known to cause a dose‐limiting nephrotoxicity, which is partially dependent on the renal uptake carrier OCT2. We here report a previously unrecognized, OCT2‐independent pathway of cisplatin‐induced renal injury that is mediated by the orga...

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Vydáno v:Clin Transl Sci
Hlavní autoři: Hu, S, Leblanc, AF, Gibson, AA, Hong, KW, Kim, JY, Janke, LJ, Li, L, Vasilyeva, A, Finkelstein, DB, Sprowl, JA, Sweet, DH, Schlatter, E, Ciarimboli, G, Schellens, JHM, Baker, SD, Pabla, N, Sparreboom, A
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593168/
https://ncbi.nlm.nih.gov/pubmed/28689374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12480
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