Conformationally organized lysine isosteres in Streptococcus pyogenes M protein mediate direct high-affinity binding to human plasminogen

The binding of human plasminogen (hPg) to the surface of the human pathogen group A Streptococcus pyogenes (GAS) and subsequent hPg activation to the protease plasmin generate a proteolytic surface that GAS employs to circumvent host innate immunity. Direct high-affinity binding of hPg/plasmin to pa...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Yuan, Yue, Zajicek, Jaroslav, Qiu, Cunjia, Chandrahas, Vishwanatha, Lee, Shaun W., Ploplis, Victoria A., Castellino, Francis J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2017
Pynciau:
Protein Structure and Folding
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592677/
https://ncbi.nlm.nih.gov/pubmed/28724633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.794198
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