A local α-helix drives structural evolution of streptococcal M-protein affinity for host human plasminogen

Plasminogen-binding group A streptococcal M-protein (PAM) is a signature surface virulence factor of specific strains of Group A Streptococcus pyogenes (GAS) and is an important tight binding protein for human plasminogen (hPg). After activation of PAM-bound hPg to the protease, plasmin (hPm), GAS c...

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Publicado en:Biochem J
Autores principales: Qiu, Cunjia, Yuan, Yue, Lee, Shaun W., Ploplis, Victoria A., Castellino, Francis J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7663350/
https://ncbi.nlm.nih.gov/pubmed/32270857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20200197
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