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Somatic Overgrowth Disorders of the PI3K/AKT/mTOR Pathway & Therapeutic Strategies
The phosphatidylinositol-3-kinase (PI3K)/AKT/mTOR signaling pathway plays an essential role in regulation of normal cell growth, metabolism, and survival. Somatic activating mutations in the PI3K/AKT/mTOR pathway are amongst the most common mutations identified in cancer, and have been shown to caus...
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| Publicado no: | Am J Med Genet C Semin Med Genet |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5592089/ https://ncbi.nlm.nih.gov/pubmed/27860216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajmg.c.31531 |
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