The PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challenges

The phosphatidylinositol 3 kinase (PI3K) pathway is frequently altered in cancer, including ovarian cancer (OC). Unfortunately, despite a sound biological rationale and encouraging activity in preclinical models, trials of first-generation inhibitors of mammalian target of rapamycin (mTOR) in OC hav...

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Bibliographic Details
Published in:Chin J Cancer
Main Authors: Cheaib, Bianca, Auguste, Aurélie, Leary, Alexandra
Format: Artigo
Language:Inglês
Published: Sun Yat-sen University Cancer Center 2015
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302085/
https://ncbi.nlm.nih.gov/pubmed/25556614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5732/cjc.014.10289
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