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Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities
GTPases and kinases are two predominant signaling modules that regulate cell fate. Dysregulation of Ras, a GTPase, and the three eponymous kinases that form key nodes of the associated phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K)/AKT/mTOR pathway have been implicated in many cancers, includ...
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| Publicado no: | Front Physiol |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4267178/ https://ncbi.nlm.nih.gov/pubmed/25566081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00478 |
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