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The PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challenges
The phosphatidylinositol 3 kinase (PI3K) pathway is frequently altered in cancer, including ovarian cancer (OC). Unfortunately, despite a sound biological rationale and encouraging activity in preclinical models, trials of first-generation inhibitors of mammalian target of rapamycin (mTOR) in OC hav...
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| Veröffentlicht in: | Chin J Cancer |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Sun Yat-sen University Cancer Center
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4302085/ https://ncbi.nlm.nih.gov/pubmed/25556614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5732/cjc.014.10289 |
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