d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity

Aminoglycoside antibiotics are widely used for the treatment of life-threatening bacterial infections, but cause permanent hearing loss in a substantial proportion of treated patients. The sensory hair cells of the inner ear are damaged following entry of these antibiotics via the mechano-electrical...

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Bibliographic Details
Published in:Front Cell Neurosci
Main Authors: Kirkwood, Nerissa K., O'Reilly, Molly, Derudas, Marco, Kenyon, Emma J., Huckvale, Rosemary, van Netten, Sietse M., Ward, Simon E., Richardson, Guy P., Kros, Corné J.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591855/
https://ncbi.nlm.nih.gov/pubmed/28928635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2017.00262
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