Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci

Most disease variants lie within noncoding genomic regions, making their functional interpretation challenging. Because chromatin openness strongly influences transcriptional activity, we hypothesized that cell-type-specific open chromatin regions (OCRs) might highlight disease-relevant noncoding se...

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Publicado en:Cell Stem Cell
Main Authors: Forrest, Marc P., Zhang, Hanwen, Moy, Winton, McGowan, Heather, Leites, Catherine, Dionisio, Leonardo E., Xu, Zihui, Shi, Jianxin, Sanders, Alan R., Greenleaf, William J., Cowan, Chad A., Pang, Zhiping P., Gejman, Pablo V., Penzes, Peter, Duan, Jubao
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591074/
https://ncbi.nlm.nih.gov/pubmed/28803920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.07.008
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