Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci

Most disease variants lie within noncoding genomic regions, making their functional interpretation challenging. Because chromatin openness strongly influences transcriptional activity, we hypothesized that cell-type-specific open chromatin regions (OCRs) might highlight disease-relevant noncoding se...

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Detaylı Bibliyografya
Yayımlandı:Cell Stem Cell
Asıl Yazarlar: Forrest, Marc P., Zhang, Hanwen, Moy, Winton, McGowan, Heather, Leites, Catherine, Dionisio, Leonardo E., Xu, Zihui, Shi, Jianxin, Sanders, Alan R., Greenleaf, William J., Cowan, Chad A., Pang, Zhiping P., Gejman, Pablo V., Penzes, Peter, Duan, Jubao
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591074/
https://ncbi.nlm.nih.gov/pubmed/28803920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.07.008
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