Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci

Most disease variants lie within noncoding genomic regions, making their functional interpretation challenging. Because chromatin openness strongly influences transcriptional activity, we hypothesized that cell-type-specific open chromatin regions (OCRs) might highlight disease-relevant noncoding se...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cell Stem Cell
मुख्य लेखकों: Forrest, Marc P., Zhang, Hanwen, Moy, Winton, McGowan, Heather, Leites, Catherine, Dionisio, Leonardo E., Xu, Zihui, Shi, Jianxin, Sanders, Alan R., Greenleaf, William J., Cowan, Chad A., Pang, Zhiping P., Gejman, Pablo V., Penzes, Peter, Duan, Jubao
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2017
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591074/
https://ncbi.nlm.nih.gov/pubmed/28803920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.07.008
टैग : टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!

समान संसाधन