Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci

Most disease variants lie within noncoding genomic regions, making their functional interpretation challenging. Because chromatin openness strongly influences transcriptional activity, we hypothesized that cell-type-specific open chromatin regions (OCRs) might highlight disease-relevant noncoding se...

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Publicat a:Cell Stem Cell
Autors principals: Forrest, Marc P., Zhang, Hanwen, Moy, Winton, McGowan, Heather, Leites, Catherine, Dionisio, Leonardo E., Xu, Zihui, Shi, Jianxin, Sanders, Alan R., Greenleaf, William J., Cowan, Chad A., Pang, Zhiping P., Gejman, Pablo V., Penzes, Peter, Duan, Jubao
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591074/
https://ncbi.nlm.nih.gov/pubmed/28803920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.07.008
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