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Challenges and Opportunities in Targeting the CD28/CTLA-4 Pathway in Transplantation and Autoimmunity

INTRODUCTION: T cell activation is a complex process that requires multiple cell signaling pathways, including a primary recognition signal and additional costimulatory signals. One of the best-characterized costimulatory pathways includes the Ig superfamily members CD28 and CTLA-4 and their ligands...

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Bibliografiske detaljer
Udgivet i:Expert Opin Biol Ther
Main Authors: Crepeau, Rebecca M., Ford, Mandy L.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590720/
https://ncbi.nlm.nih.gov/pubmed/28525959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14712598.2017.1333595
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