Pharmacological modulation of the voltage-gated neuronal Kv7/KCNQ/M-channel alters the intrinsic excitability and synaptic responses of pyramidal neurons in rat prefrontal cortex slices

The prefrontal cortex (PFC) critical for higher cognition is implicated in neuropsychiatric diseases, such as Alzheimer's disease, depression and schizophrenia. The voltage-activated Kv7/KCNQ/M-channel or M-current modulates the neuronal excitability that defines the fundamental mechanism of br...

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Bibliographic Details
Published in:Acta Pharmacol Sin
Main Authors: Peng, Hui, Bian, Xi-ling, Ma, Fu-cui, Wang, Ke-Wei
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589969/
https://ncbi.nlm.nih.gov/pubmed/28603289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.72
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