Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness

Obscurins are a family of RhoGEF-containing proteins with tumor and metastasis suppressing roles in breast epithelium. Downregulation of giant obscurins in normal breast epithelial cells leads to reduced levels of active RhoA and of its downstream effectors. Herein, we elucidate how depletion of gia...

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Pubblicato in:Oncotarget
Autori principali: Stroka, Kimberly M., Wong, Bin Sheng, Shriver, Marey, Phillip, Jude M., Wirtz, Denis, Kontrogianni-Konstantopoulos, Aikaterini, Konstantopoulos, Konstantinos
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589558/
https://ncbi.nlm.nih.gov/pubmed/28903319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10997
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