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Loss of giant obscurins promotes breast epithelial cell survival through apoptotic resistance
Obscurins (∼70–-870 kDa), encoded by the single OBSCN gene, are cytoskeletal proteins originally identified in striated muscles with structural and regulatory roles. Recently, analysis of 13,023 genes in breast and colorectal cancers identified OBSCN as one of the most frequently mutated genes, impl...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Federation of American Societies for Experimental Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4046098/ https://ncbi.nlm.nih.gov/pubmed/22441987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-205419 |
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