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Loss of giant obscurins promotes breast epithelial cell survival through apoptotic resistance
Obscurins (∼70–-870 kDa), encoded by the single OBSCN gene, are cytoskeletal proteins originally identified in striated muscles with structural and regulatory roles. Recently, analysis of 13,023 genes in breast and colorectal cancers identified OBSCN as one of the most frequently mutated genes, impl...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Federation of American Societies for Experimental Biology
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4046098/ https://ncbi.nlm.nih.gov/pubmed/22441987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-205419 |
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