Loss of giant obscurins promotes breast epithelial cell survival through apoptotic resistance

Obscurins (∼70–-870 kDa), encoded by the single OBSCN gene, are cytoskeletal proteins originally identified in striated muscles with structural and regulatory roles. Recently, analysis of 13,023 genes in breast and colorectal cancers identified OBSCN as one of the most frequently mutated genes, impl...

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Bibliographic Details
Main Authors: Perry, Nicole A., Shriver, Marey, Mameza, Marie G., Grabias, Bryan, Balzer, Eric, Kontrogianni-Konstantopoulos, Aikaterini
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2012
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046098/
https://ncbi.nlm.nih.gov/pubmed/22441987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-205419
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