Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis

Obscurins, encoded by the single OBSCN gene, are giant cytoskeletal proteins with structural and regulatory roles. The OBSCN gene is highly mutated in different types of cancers. Loss of giant obscurins from breast epithelial cells confers them with a survival and growth advantage, following exposur...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Shriver, M, Stroka, KM, Vitolo, MI, Martin, S, Huso, DL, Konstantopoulos, K, Kontrogianni-Konstantopoulos, A
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426246/
https://ncbi.nlm.nih.gov/pubmed/25381817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.358
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