Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis

Obscurins, encoded by the single OBSCN gene, are giant cytoskeletal proteins with structural and regulatory roles. The OBSCN gene is highly mutated in different types of cancers. Loss of giant obscurins from breast epithelial cells confers them with a survival and growth advantage, following exposur...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Shriver, M, Stroka, KM, Vitolo, MI, Martin, S, Huso, DL, Konstantopoulos, K, Kontrogianni-Konstantopoulos, A
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426246/
https://ncbi.nlm.nih.gov/pubmed/25381817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.358
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