Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness

Obscurins are a family of RhoGEF-containing proteins with tumor and metastasis suppressing roles in breast epithelium. Downregulation of giant obscurins in normal breast epithelial cells leads to reduced levels of active RhoA and of its downstream effectors. Herein, we elucidate how depletion of gia...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Stroka, Kimberly M., Wong, Bin Sheng, Shriver, Marey, Phillip, Jude M., Wirtz, Denis, Kontrogianni-Konstantopoulos, Aikaterini, Konstantopoulos, Konstantinos
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589558/
https://ncbi.nlm.nih.gov/pubmed/28903319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10997
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