KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination

Maintenance of muscle function requires assembly of contractile proteins into highly organized sarcomeres. Mutations in Kelch-like protein 41 (KLHL41) cause nemaline myopathy, a fatal muscle disorder associated with sarcomere disarray. We generated KLHL41 mutant mice, which display lethal disruption...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Ramirez-Martinez, Andres, Cenik, Bercin Kutluk, Bezprozvannaya, Svetlana, Chen, Beibei, Bassel-Duby, Rhonda, Liu, Ning, Olson, Eric N
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2017
Pynciau:
Cell Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589419/
https://ncbi.nlm.nih.gov/pubmed/28826497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26439
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